Abstract
BackgroundAim of this in-vitro-study was to assess the remineralization potential of a tooth cleaning tablet with different fluoride content.MethodsTwenty three caries free impacted third molars were examined, enamel surfaces were wax coated leaving two 3 × 4 mm windows for exposure to demineralization/remineralization cycles. The teeth were randomly assigned to 4 groups of 5 control and 6 experimental teeth. Demineralization by standardised HEC-gel, pH 4.7 at 37°C for 72 h, was alternated by rinsing in remineralization solution, pH 7.0 at 37°C for 72 h, total challenge time 432 h. The negative control group N was treated during remineralization cycles with saline; positive control group P was treated with remineralization solution; experimental group D1 was exposed to remineralization solution containing Denttabs®-tablets with 1450 ppm F; experimental group D2 was exposed to remineralization solution and Denttabs®-tablets with 4350 ppm F. Each tooth was cut into serial sections and analyzed by polarized light microscopy for assessment of the different zones of white-spot lesions in 3 representative sections. Statistical analysis was based on the Mann-Whitney-Test.ResultsBoth control groups N(-) and P(+) exhibited characteristic white-spot lesions. The remineralization and the demineralization inhibition of the lesions increased considerably from N<P < D1<D2. Denttabs®-2 administration showed partial/total remineralization including lamination and/or disappearance of the body of the lesion. The different results of all 4 groups were statistically highly significant (p < 0.01) with both tests.ConclusionBased on these results the novel Denttabs® formulation represents a highly effective oral hygiene product and the remineralization is correlated to the fluoride content.
Highlights
Aim of this in-vitro-study was to assess the remineralization potential of a tooth cleaning tablet with different fluoride content
The long or even life long presence of the human dentition combined with dietary influences and individual tooth brushing habits may lead to the risk of erosive and/or abrasive lesions of enamel and especially of root dentin
The negative control group N showed rather homogeneous advanced white-spot lesions, whereas in the positive control group P the white spot lesions were less homogeneous with color changes
Summary
Aim of this in-vitro-study was to assess the remineralization potential of a tooth cleaning tablet with different fluoride content. The long or even life long presence of the human dentition combined with dietary influences and individual tooth brushing habits may lead to the risk of erosive and/or abrasive lesions of enamel and especially of root dentin. It was the aim of the development of an oral hygiene agent in tablet form to increase the fluoride availability in oral fluids and to substitute the abrading effect of many traditional toothpastes by a polishing action due to microcrystalline hydroxyethyl cellulose. The resulting product (Denttabs®, Prodentum, Berlin, Germany) is rapidly dissolved in saliva, and the fluoride bioavailability immediatedly after tooth brushing and 10 minutes after tooth brushing is higher (Median 165.2 ppm F-) compared to a conventional dentifrice foam/saliva mixture (Median 123.7 ppm F-) (Naumova et al, Fluoride bioavailability in saliva after using DENTTABS® compared to dentifrice, submitted).
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