Abstract
The effect of aflatoxin B 1 on the uptake and incorporation of [ 3H]leucine and [ 3H]uridine and on phagocytosis of latex particles was studied using cultures of rat liver macrophages (Kuffer cells). Aflatoxin B 1 inhibited the incorporation of both isotopes, but inhibition of uridine incorporation was greater than that of leucine, suggesting that RNA synthesis was a major site of inhibition. Aflatoxin b 1also inhibited phagocytosis of latex particles in a time- and dose-dependent manner.
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