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Abstract
The metabolism of progesterone-4-14C by mouse adrenals was studied in vitro following incubation with the inhibitor, 2-methyl-l,2-bis(3-pyridyl) -1-propanone(Su- 4885) alone, and in the presence of added NADPH. Su-4885 (5×10-5M) inhibited the conversion of progesterone to compounds more polar than corticosterone, as well as to corticosterone itself, with a corresponding accumulation of a number of less polar compounds, particularly ring A reduced metabolites of progesterone and deoxycorticosterone. The addition of NADPH accentuated these reductive pathways. Consideration is given to the possible functional role of reductive pathways in the adrenal cortex. (Endocrinology 75: 949, 1964)
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