Abstract
1. MPTP significantly lowered K d of the binding of [ 3H]QNB to muscarine receptor without affecting B max values compared with those of control. Hill coefficients (nH) of control and MPTP (250 μM) added group were 1.15 ± 0.127 and 0.56 ±0.202, respectively. 2. Prior addition of pargyline to MPTP did not prevent the decrease of [ 3H]QNB binding. The patterns of displacement of [ 3H]QNB by MPTP and MPP + were similar to those by some muscarinic agonists, such as acetylcholine, carbamyl choline and methacholine. 3. These results suggest that MPTP might be muscarinic agonist and might play a role to produce Parkinsonism through directly affecting the muscarinic cholinergic receptors in vivo.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Comparative Biochemistry and Physiology. Part C, Comparative Pharmacology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
