Abstract
In this paper, we demonstrate the preparation of silibinin-loaded carbon nanotubes (SWSB) with surface coating agents via non-covalent approach as an effective drug delivery system. The resulting surface-coated SWSB nanocomposites are extensively characterized by Fourier transform infrared (FTIR) and Raman spectroscopies, ultraviolet–visible (UV–Vis) spectrometry and field emission scanning electron microscopy (FESEM). The FTIR and Raman studies show that an additional layer is formed by these coating agents in the prepared nanocomposites during the coating treatment and these results are confirmed by FESEM. Drug loading and release profiles of the coated SWSB nanocomposites in phosphate buffered saline solution at pH 7.4 is evaluated by UV–Vis spectrometry. The in vitro results indicate that the surface-modified nanocomposites, with SB loading of 45 wt%, altered the initial burst and thus, resulted in a more prolonged and sustained release of SB. In addition, these nanocomposites exhibit a pseudo-second-order release kinetic which was driven by the ion exchange between the ionized SWSB and the anions in the release medium. The cytotoxicity effect of the resulting nanocomposites on normal mouse fibroblast cells is evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. It is observed that the surfactant and polymer coating improved the biocompatibility of the SWSB nanocomposites significantly, which deem further exploitation for their application as potential anticancer drug delivery system.
Highlights
Cancer, a common name given to a group of related illnesses, has a great impact on public health across the world
Fourier transform infrared The characteristic bands of SWCNT-COOH, SB and the final product, SWSB (Fig. 1a) have been discussed in our previous paper and in this work the emphasis is being placed on the surface-coated SWSB nanocomposites
In order to achieve better dispersion and improved biocompatibility, T20, T80, polyethylene glycol (PEG) and CS were used as a coating agent separately
Summary
A common name given to a group of related illnesses, has a great impact on public health across the world. According to the source which was published recently, American men have a slightly higher risk for developing cancer (less than 1 in 2) compared to women (a little more than 1 in 3) over the course of their lifetimes. These figures reveal that, cancer rates are Chemotherapy is the drug treatment for cancer disease using powerful chemicals, and it is expected to kill the cancer cells for maximum treatment efficacy without destroying other normal cells in the body. It is essentially important for medicinal chemists to alter the drug actions by developing a well-designed drug delivery system with specific tumour-targeting and pHtriggered unloading properties, while reducing unwanted
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