Abstract
Los normal samples of dapsone (DDS) were prepared in which the geometric mean diameter ranged from 20 to 50 micron while the geometric standard deviation was in the range 1.62 to 1.88. Using a simple in vitro flow-through dissolution cell at 37 degrees C, the data obtained were found to fit the Hixson-Crowell cube root dissolution law up to a critical time, Tc, where a distinct break occurred. Such a biphasic phenomenon has been predicted by other workers and is related to the time at which the smallest particles present have undergone dissolution. The initial slopes of the cube root dissolution plots were shown to be directly related to the reciprocal of the geometric mean diameter.
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