Abstract
Aims: Recently, a new approach to reprogram somatic cells to pluripotent stem cells was shown by fusion of somatic cells with embryonic stem cells (ESC), avoiding generation of totipotent embryos. These fusion hybrids morphologically resemble normal ESCs but have a tetraploid karyotype. Normal hepatocytes often are polyploid, so we preferentially investigate the differentiation potential of fusion hybrids into hepatic cells.
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