Abstract
In vitro Differentiation of Adipose Derived Stem Cells into Functional Dopaminergic Neurons
Highlights
Parkinson’s disease (PD) known as a neurodegenerative disorder whose symptoms of resting tremor, rigidity, and bradykinesia are caused by the degeneration of dopamine (DA) neurons in the midbrain
Immunophenotyping of adiposederived stem cells (ADSCs) displayed these cells as positive cells for mesenchymal stem cells markers such as CD105 and CD73
One potential issue ahead in this context was the finding of feasible population cells for replacement therapies and transplantation in specific regions of the brain that involve in neurodegeneration. It seems that using ADSCs are a suitable source of cells for transplantation as they are available and could be isolated beside their ability for being rapidly expanded and differentiated into neuronal cells (4, 5, 26)
Summary
Parkinson’s disease (PD) known as a neurodegenerative disorder whose symptoms of resting tremor, rigidity, and bradykinesia are caused by the degeneration of dopamine (DA) neurons in the midbrain. Adipose tissue has been known as multi-potent stem cells assigned the generic nomenclature, adiposederived stem cells (ADSCs)[5, 6] These cells can be differentiated to various mesenchymal tissues such as chondrocytes, myocytes ,adipocytes and osteoblasts[7,8,9]. One promising source of renewable cells for transplantation in PD are human neural progenitor cells (hNPs) derived from pluripotent human embryonic stem (hESCs) cell lines. Their success, greatly depends on the discovery of ways to promote their proper differentiation into midbrain dopamine (mDA) neurons. There are findings about derivation of DA neurons from ESCs . 11-13 Even so, using of ESCs for transplantation can be led to immune rejection because of forming teratomas
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