In- vitro Design and Formulation of Levitiracetam Extended Release Tablets

Abstract

The objective of the present study is to evaluate the extended release tablets of levitiracetam by using HPMC K100, HPMC K15 and Xanthan gum/Ethyl cellulose effect of the dissolution rate of tablets. Tablet each containing 60mg of Levetiracetam were prepared selected combination of factors to evaluate their individual and interaction effects on dissolution rate. The FTIR spectra of pure drug and mixture with various excipients are similar. It’s indicates no chemical intration between drug and excipients. The drug release from all the tablets was diffusion control as indicated by the linear Higuchi plots. The release data was analysed Peppas equation the release exponent (n) was found to be in the range 0.76-0.93. Amount all the levetiracetam tablets prepared formulation F2 (fa) formulated employing HPMC K100, 60mg, HMPC K15, 25mg , Xanthane gum 25mg. In the all cases formulations F1, F3, F4, F5, F8 Indicates non fickain diffusion and F2, F6, F7 Indicates super case II transport as release mechanism. The formulation F2 (Fa) was released 100% drug release in a 8 hrs. It is fulfil specifications for extended release tablets. The results of ANOVA of Ko values indicated that the individual and combined effect of the 3 factors is significant (P< 0.05).