Abstract
Blank and bovine serum albumin (BSA)-loaded microspheres based on poly(lactic-acid- alt-glycolic acid) ( d, l-PLGA50) and poly(ε-caprolactone)-b-poly(lactic-acid- alt-glycolic acid) (PCL-b- d, l-PLGA50) were successfully fabricated using water-in-oil-in-water (w/o/w) double-emulsion extraction/evaporation technique. In vitro degradation of the blank microspheres was characterized by techniques including nuclear magnetic resonance ( 1H NMR), gel permeation chromatography (GPC), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). The PCL-b- d, l-PLGA50 copolymer ( M n: number-average molecular weight, M w: weight-average molecular weight, M n = 44800, M w / M n = MWD = 1.24, ε-caprolactone (CL) % = 20.4% in molar ratio) had similar rate of molecular weight reduction compared with the d, l-PLGA50 copolymer before 5 weeks of in vitro degradation. The BSA % loading efficiency of microspheres was mainly controlled by both block copolymer composition and macromolecular architecture, while the sequence structure and the molecular weight of copolymer had no apparent effect on it. Significantly, The PCL-b- d, l-PLGA50 copolymer microspheres showed good release profiles with a nearly constant release during 20−110 days.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
