Abstract
Titanium dioxide nanotubes were synthesized by anodizing Ti sheets in the ethylene glycol solution and were covered in Pt nanoparticles onto the surface of TiO2NTs using electrodeposition method from using five derivatives of Mannich base Pt complexes which have been used as precursor of platinum. The mean size, shape, elemental composition of the titanium dioxide nanotubes and platinum deposited on the template were evaluated by different techniques such as field emission scanning electron microscope (FE-SEM), transmission electron microscopy (TEM), X-ray diffraction pattern (XRD), and energy dispersive X-ray (EDX) technique. From all these analyses, the TiO2NTs prepared and Ptnanoparticles deposited on it were identified. The diagnoses proved that all the Pt nanoparticles have a size less than 50 nm. The MCF-7 cancer cell lines and WRL68 normal cell lines were treated with concentration 800, 400,200,100, 50, 25, 12.5µg\ml of TiO2NTs and Pt\TiO2NTs(1) and (2) for 48hours using MTT assay.IC50 and inhibition rate were calculated. The result shows that the Pt\TiO2NTs have more inhibition effect on cancer cell lines than TiO2NTs array.
Highlights
Most recent research on titanium dioxide nanotubes interested in the doping or deposition of metal ions like chromium, iron, cobalt, nickel,copper, palladium, platinum, sliver, and zirconium [1] and like boron,carbon, nitrogen and fluoride as non-metal in addition to using the metal oxides such as manganese dioxide had increased its applications in several fields [2]
In this research titanium nanotubes were prepared and different sizes of Pt nanoparticles deposited on the surface of titanium nanotubes using different deposition times 3minutes when using PtL1,PtL2,PtL3 and PtL5 and 6 minutes when use PtL4.at the fixed concentration to show the effect of the size and density of platinum nanoparticles and their effect on inhibition of cancer cells compared to nanotubes alone by using MTT method in 620nm.This research aims to synthesis pt nanoparticles of different size from Mannich base platinum complexes as a source of platinum after deposition on TiO2NTs and study the cytotoxic effect of these nanomaterials on breast cancer cell lines
Pt nanoparticles prepared at 7 V, 2 mM for 6 minutes, became larger than Pt synthesized at 3minutes [24]
Summary
Most recent research on titanium dioxide nanotubes interested in the doping or deposition of metal ions like chromium, iron, cobalt, nickel ,copper, palladium, platinum, sliver, and zirconium [1] and like boron ,carbon, nitrogen and fluoride as non-metal in addition to using the metal oxides such as manganese dioxide had increased its applications in several fields [2]. Consistent with several researchers, the titanium oxide nanotubes could have been employed in drug-eluting stents and for the native unleash of antibiotics, drug delivery in cancer and tumor therapy. It is widely used in dental implants and bones [11]. In this research titanium nanotubes were prepared and different sizes of Pt nanoparticles deposited on the surface of titanium nanotubes using different deposition times 3minutes when using PtL1,PtL2,PtL3 and PtL5 and 6 minutes when use PtL4.at the fixed concentration to show the effect of the size and density of platinum nanoparticles and their effect on inhibition of cancer cells compared to nanotubes alone by using MTT method in 620nm.This research aims to synthesis pt nanoparticles of different size from Mannich base platinum complexes as a source of platinum after deposition on TiO2NTs and study the cytotoxic effect of these nanomaterials on breast cancer cell lines
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