In Vitro Cytotoxicity of a Ti-35Nb-7Zr-5Ta Alloy Doped with Different Oxygen Contents

Tatiani Donato,Victor Arana-Chavez,Carlos Grandini,Luciano De Almeida

doi:10.3390/ma7032183

Tatiani Donato, Victor Arana-Chavez + Show 2 more

Open Access

https://doi.org/10.3390/ma7032183

Copy DOI

Abstract

Cp-Ti is the most common material used for dental implants, but its elastic modulus is around five times higher than that of bone. Recently, promising alloys that add Nb, Ta, Zr and Mo to Ti have been developed. The mechanical properties of these alloys are directly related to its microstructure and the presence of interstitial elements, such as oxygen, carbon, nitrogen and hydrogen. In this study, the in vitro cytotoxicity of Ti-35Nb-7Zr-5Ta (TNZT) alloys was analyzed in the as-received condition and after being doped with several small quantities of oxygen on a cultured osteogenic cell. The cell’s morphology was also examined by scanning electron microscopy (SEM). The TNZT alloy presented no cytotoxic effects on osteoblastic cells in the studied conditions.

Highlights

A desirable biomaterial should be predicable and capable of allowing controlled, guided and rapid healing of the host tissue
The aim of the present study is to investigate the biocompatibility of a TNZT alloy doped with different oxygen contents on bone cells by using in vitro cytotoxicity tests and scanning electron microscopy
The results show that the concentration of substitutional elements is very close to the stoichiometry, demonstrating the good quality of the produced samples

Summary

Introduction

A desirable biomaterial should be predicable and capable of allowing controlled, guided and rapid healing of the host tissue. A high amount of aluminum interferes with cell viability, besides having a long-term cytotoxic effect in vitro and in vivo [3,4] This alloy still has a relatively high modulus (about 120 GPa) when compared with that of bone (about 28 GPa) [5]. In spite of reducing the elasticity modulus of titanium alloys without causing cytotoxic effects, new promising alloys that add niobium, tantalum, zirconium and molybdenum to titanium have been developed These alloys represent a new class of titanium-based alloys, which are free of aluminum and vanadium, while exhibiting low values of the Young’s modulus; these qualities render them quite attractive as biomaterials [5,6]. The aim of the present study is to investigate the biocompatibility of a TNZT alloy doped with different oxygen contents on bone cells by using in vitro cytotoxicity tests and scanning electron microscopy

Results and Discussion

Experimental Section

Conclusions