Abstract
Objective: The present study was conducted to evaluate the in vitro cytotoxic activity and α- amylase inhibitory activity of secoisolariciresinol diglucoside (SDG).
 Methods: The cytotoxic activity was conducted on HT-29 (human colon cancer cell line) and PA-1 (human ovarian cancer cell line) by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay and the α- amylase inhibitory activity using acarbose as a standard. Both the tests were evaluated at different concentrations, 3.125–100 μg/ml and 50–2000 μg correspondingly and the concentration required for a 50% inhibition of viability (IC50) was determined graphically. The effect of the samples on the proliferation of HT-29 and PA-1 was expressed as the percentage cell viability.
 Results: SDG exhibited a considerable dose- and time-dependent inhibition on both HT-29 and PA-1 and also observed a concentration-dependent α-amylase inhibitory activity that leads in reduction of starch hydrolysis and hence eventually to lowered glucose levels.
 Conclusion: The present in vitro study concluded that SDG can be a potent anticancer and moderate hyperglycemic component.
Highlights
Cancer is a communal health problem all over the world which may affect many different parts of the body
secoisolariciresinol diglucoside (SDG) exhibited a considerable dose- and time-dependent inhibition on both HT-29 and PA-1 and observed a concentration-dependent α-amylase inhibitory activity that leads in reduction of starch hydrolysis and eventually to lowered glucose levels
The present in vitro study concluded that SDG can be a potent anticancer and moderate hyperglycemic component
Summary
Cancer is a communal health problem all over the world which may affect many different parts of the body. Plants are the source of medicine from thousands of years and phytochemicals are continued to play an essential role in medicine. The use of medicinal plant extracts for the treatment of human diseases is an ancient practice; this has greatly increased in recent years. Plants are being used in the treatment of cancer [2]. Man searches for drugs from different sources such as preserved monuments, writer documents, and from plants [3]. Plants were playing an important and key role in food and drug administration [4]. Medicinal plants are considered as a healthy source of human life due to their therapeutical capacities in the treatment of different diseases [5]
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