Abstract
In vitro studies were carried out to evaluate the cytotoxic potential of the ethanolic and aqueous extracts from stem of Dendrophthoe falcata against human breast cancer cells (MCF-7). Screening of these extracts was done using the brine shrimp lethality bioassay, MTT assay and SRB assay. The results showed the significant decrease of the viability of the cells in a concentration-dependent manner. The ethanolic extract of D. falcata showed IC50 107 μg mL-1 in MTT assay and 112 μg mL-1 in SRB assay for MCF-7 cells and thus showed significant cytotoxic activity. The aqueous extract of D. falcata demonstrated higher activity with IC50 90 μg mL-1 in MTT and 98 μg mL-1 in SRB assay for MCF-7 cells, respectively after 48 h of exposure. In brine shrimp lethality bioassay also aqueous extract showed more potent cytotoxicity with LC50 90 μg mL-1 as compared to ethanolic extract with LC50 120 μg mL-1. From results obtained it was observed that both extracts of D. falcata may be a promising alternative to synthetic substances as natural compound with high antiproliferative activities and to be useful in cancer treatment and prevention.
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