Abstract
Cytogenetic effects after varied times of exposure to calcium cyclamate, cyclohexylamine (CHA) or triflupromazine HCl (TFP) were determined in a cell line derived from the kidney of the rat kangaroo ( Potorous tridactylis apicalis). A preliminary study, using aflatoxin and mitomycin C, which are known to produce abnormalities in cell systems, established the suitability of this cell line for the detection of chromosomal aberrations. In the present study, mitomycin C produced frequent chromatid gaps and breaks in the arms of the chromosomes. Aberrations of the chromosome-type as well as exchanges were noted with aflatoxin. The X-chromosome was extremely sensitive to these agents. CHA produced single chromatid breaks and TFP produced single chromatid breaks and exchange figures. The X-chromosome was not exceptionally sensitive to either of these agents. Calcium cyclamate at concentrations up to 200 μg/ml produced no chromosomal aberrations.
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