Abstract
[7-3H]-Pregnenolone was incubated with homogenates of discrete limbic brain areas from male rats, in the presence of NAD, and its conversion to [7-3H]-progesterone was quantitatively determined. The highest conversion occurred in amygdalar tissue, followed by septum. Lower conversion occurred in hippocampus and hypothalamus, while no significant conversion could be detected in cerebral cortical tissue. These results demonstrate the presence of 3β-hydroxysteroid oxidoreductase, 5-ene-isomerase in the male rat limbic brain. The possible physiological significance of this presence is discussed.
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