Abstract
The axially silicon phthalocyanines, consisting of different acyclic hydrocarbons, were generated by SiPcCl2 reacting with either geraniol or phytol in toluene in the presence of NaH. FT-IR, UV–Vis, MALDI TOF, and NMR spectroscopy all provided information about the structures of silicon phthalocyanines. The cholinesterase, tyrosinase, and α-glucosidase inhibitory effects of G-SiPc and P-SiPc were tested using spectrophotometric assays. The IC50 values of G-SiPc and P-SiPc were 7.22 ± 0.53 and 11.28 ± 2.73 µM for AChE; 70.05 ± 3.00 and 60.55 ± 3.80 µM for BuChE. In addition, G-SiPc and P-SiPc inhibited the tyrosinase enzyme with IC50 values of 280.36 ± 7.92 µM and 40.51 ± 3.88 µM, respectively. P-SiPc had about seven times stronger inhibitory properties than G-SiPc. The substances exhibited less inhibition than acarbose in the α-glucosidase inhibitory assay. Finally, the cytotoxic effects of G-SiPc and P-SiPc were investigated using the MTT assay on L-929 mouse fibroblast cells as normal cells. G-SiPc and P-SiPc did not reach IC50 values up to 100 μM.
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