Abstract
Periodontitis is one of the most common infectious diseases globally that, if untreated, leads to destruction of the tooth supporting tissues and finally results in tooth loss. Evidence shows that standard procedures as mechanical root cleaning could be supported by further treatment options such as locally applied substances. Due to gingival crevicular fluid flow, substances are commonly washed out off the periodontal pockets. The evaluation of administration techniques and the development of local drug releasing devices is thus an important aspect in periodontal research. This study describes the development and examination of a new alginate based, biodegradable and easily applicable drug delivery system for chlorhexidine (CHX). Different micro beads were produced and loaded with CHX and the release profiles were investigated by high performance liquid chromatography (HPLC). The in vitro-demonstrated release of CHX from alginate based beads shows comparable releasing characteristics as clinically approved systems. Yet many characteristics of this new delivery system show to be favourable for periodontal therapy. Easy application by injection, low production costs and multifunctional adaptions to patient related specifics may improve the usage in routine care.
Highlights
Gingivitis and periodontitis are infectious diseases caused by bacteria
Artifical saliva free of sorbic acid was used for high performance liquid chromatography (HPLC)-measurements and prepared with reagents listed above
To investigate drug release a High Performance Liquid Chromatography System (HPLC) from Knauer, Berlin, Germany was used under the following conditions: column Eurospher 100 C18, 250 x 4 mm, mobile phase: acetonitrile/0.08M NaH2PO4 + 0.5% triethylamine, pH 3.0 (350/650 v/v), isocratic flow rate: 1 ml/min, temperature: 20 ̊C, detection wavelength: UV 251 nm, injected sample volume: 20 μl
Summary
Gingivitis and periodontitis are infectious diseases caused by bacteria. Untreated periodontitis lead to the destruction of the tooth supporting tissues and may result in tooth loss. Periodontitis is one of the most common infectious diseases. In the United states of America 46% of all adults aged ! 30 years (representing 64.7 million people) suffer from periodontitis. [1] Severe forms, with periodontal pockets deeper than 6mm, differ from 10% to 15% worldwide.[2] In Germany almost every second (52%) young adult (aged 35–44 years) in Germany suffers from a periodontal disease.[3] Due to the demographic change and relations between periodontitis and other common diseases as diabetes and cardiovascular diseases, there will be an increasing therapy demand.[3] [4], [5], [6]
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