Abstract
INTRODUCTION: Candida parapsilosis complex species differ from each other with regard to their prevalence and virulence. METHODS: The hydrolytic enzyme activity, biofilm production, and adhesion to epithelial cells were analyzed in 87 C. parapsilosis complex strains. RESULTS: Among the studied isolates, 97.7%, 63.2%, and 82.8% exhibited very strong proteinase, esterase, and hemolysin activity, respectively. All the C. parapsilosis complex isolates produced biofilms and presented an average adherence of 96.0 yeasts/100 epithelial cells. CONCLUSIONS: Our results show that Candida parapsilosis complex isolates showed different levels of enzyme activity, biofilm production, and adhesion to epithelial cells.
Highlights
Candida parapsilosis complex species differ from each other with regard to their prevalence and virulence
We evaluated the in vitro capacity of C. parapsilosis sensu stricto, C. orthopsilosis, and C. metapsilosis isolates to produce hydrolytic enzymes, to adhere to human buccal epithelial cells, and produce biofilm
Different results were obtained by Treviño-Rangel et al.[2], who observed esterase production in 13.3% of C. parapsilosis and 66.6% of C. orthopsilosis isolates studied but not in any C. metapsilosis isolates
Summary
Candida parapsilosis complex species differ from each other with regard to their prevalence and virulence. We evaluated the in vitro capacity of C. parapsilosis sensu stricto, C. orthopsilosis, and C. metapsilosis isolates to produce hydrolytic enzymes, to adhere to human buccal epithelial cells, and produce biofilm. C. parapsilosis sensu stricto isolates produced mean Pz of esterase activity higher than the others (p = 0.015), especially in blood samples (p = 0.025) (Table 2).
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