Abstract
The major downside of conventional chemo-therapeutics is their lenient distribution in the body which brings about consequential knock-on to well cells. As out-turn, the concentration of drug extends to the tumor is bring down, ensuring suboptimal therapeutic efficacy. Non-ionic surfactant vesicles (niosome) were drawn up with a point of upgrading the therapeutic presence of the molecules of the drug by shielding the drug. Doxorubicin (DOX), an anti-cancer drug, from the biological environment, results in controlled drug delivery and better availability. Niosome were formulated by the method of conventional thin-film hydration using cholesterol and pluronic P123. Doxorubicin was enclosed in the niosome with an elevated entrapment efficiency of 88%. Their diameter was about 200 nm. The discharged drug by the vesicles was spotted to be managed and sustained for over 24 h at pH 7.4, followed by a Higuchi kinetic release mechanism. In closing, niosome might be an auspicious delivery for DOX with refined targeted drug delivery.
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