In vitro characterization of [3H]-T808 (tau PET tracer) binding in human brain tissues in Alzheimer's disease

Abstract

datasets allowed to significantly differentiate between AD and non-AD based on WBV and LVV, and between each groups based on HCV. ROC analysis led to similar area under the curve (AUC) when attempting to separate NC and AD subjects using accelerated data, non-accelerated data and random combinations (see Table 1).Conclusions: The use of parallel imaging did not exhibit any impact on volumetric measurements (ICV, HCV, WBVand LVV). This supports the idea that its use in clinical trials MR protocols with a volumetric component should be highly encouraged for faster acquisition and decreased occurrence of motion artifacts. The impact on subsequent atrophy measurements will have to be assessed as well.