Abstract
AbstractAntimicrobial activities of methanolic and petroleum ether extracts of Croccus sativus L. (saffron) stigmas, were tested against various bacterial strains (Proteus vulgaris, Klebsiella pneumonia, Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli) and fungi (Candida albicans, Aspergillus niger and Aspergillus fumigatus) by agar well diffusion method. Minimal inhibitory concentration and minimum bactericidal and fungicidal concentration values of each active extract were also determined. The results showed a strong activity of the petroleum ether and methanolic extracts of saffron stigmas against bacteria and fungi used as test organisms. The results of different antimicrobial assays also indicate that the extracts had significantly higher bactericidal than fungicidal activities (p < 0.05). The results suggest that these extracts can be used in pharmaceutical and food formulations for inhibiting pathogenic bacterial and fungal species.
Highlights
Antimicrobial activity of C. sativus extracts The test for antimicrobial effect of petroleum ether and methanolic extracts of C. sativus stigmas represents an important source of substances with antimicrobial activity
Similar results were reported by earlier workers (Soureshjan & Heidari, 2014), who found an increase in antimicrobial activity of Glaucium elegans and Crocus stavius extracts with increasing concentrations
The results indicated that no antimicrobial activity was observed against A. niger and A. fumigatus by petroleum ether and against C. albicans and A. niger by methanolic extracts at 500 μg/disc dosage level
Summary
Syed Muzaffar is an assistant professor at Government Amar Sing College, Srinagar, J and K, India and is doing PhD, at Department of Chemistry, University of Kashmir His core areas of research is nutraceutical potential of saffron. Interest in the antimicrobial properties of active compounds is strengthened by the findings that they affect the behaviour of pathogenic bacteria or fungi of agro-food or medical field. Their use as natural additives in food industry is increased in recent years (Nazzaro et al, 2009). In this work we examine the in vitro antimicrobial activities of petroleum ether and methanolic extracts of C. sativus stigmas obtained from Jammu and Kashmir, India
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