Abstract
BackgroundDenture with antimicrobial activities is desirable to prevent Candida albican adhesion subsequently decreasing the susceptibility of denture stomatitis incidence. Azadirachta Indica, commonly known as Neem powder has antimicrobial effect but the effect of its addition to acrylic denture base on C. albicans adhesion has not been investigated. The aim of this study was determine whether adding neem powder to acrylic denture base materials could reduce Candida albicansadhesion.Material and MethodsOne hundred and twenty acrylic resin denture specimens were fabricated and divided into heat-polymerized (n=60) and auto-polymerized (n=60) groups. Each group was further divided into 6 groups (n=10) based on the neem concentration: 0, 0.5, 1, 1.5, 2 and 2.5 wt% of the polymer. After polymerization, the specimens were polished, stored in distilled water, sonicated, sterilized, submerged in artificial saliva containing C. albicans, and finally, placed in an incubator at 37°C. Slide counting and direct culture methods were used to assess the antifungal effects of the neem addition. An analysis of variance and post hoc Tukey’s test were performed for the data analysis (p≤0.05 was statistically significant).ResultsBased on the results, the neem addition significantly decreased the C. albicans count when compared to the control group (p≤0.05). Moreover, the count decreased as the neem concentration increased (lowest count with 2.5 wt%).ConclusionsThe results suggest that adding neem powder to acrylic resin denture base materials reduces the adhesion of C. albicans; therefore, the incorporation of neem could be a possible denture stomatitis prevention method. Key words:Denture stomatitis, Candida albicans, Azadirachta indica, neem powder, denture base.
Highlights
Denture stomatitis (DS) is a widespread disease occurring in both partial and complete denture wearers that tends to affect the mucosa of the palate [1]
The antifungal effects of TQ incorporated into polymethyl methacrylate (PMMA) denture base materials were investigated by Al-Thobity et al They concluded that the addition of TQ could be effective for preventing C. albicans adhesion and proliferation on the denture surface as one possible method for preventing DS [13]
The aim of the present study was to evaluate the effects of incorporating neem into PMMA denture base materials on C. albicans as a new approach for DS prevention and treatment
Summary
Denture stomatitis (DS) is a widespread disease occurring in both partial and complete denture wearers that tends to affect the mucosa of the palate [1]. The antifungal effects of TQ incorporated into polymethyl methacrylate (PMMA) denture base materials were investigated by Al-Thobity et al They concluded that the addition of TQ could be effective for preventing C. albicans adhesion and proliferation on the denture surface as one possible method for preventing DS [13]. The null hypothesis of this study was that the incorporation of neem powder into PMMA denture base materials would not decrease C. albicans adhesion. Azadirachta Indica, commonly known as Neem powder has antimicrobial effect but the effect of its addition to acrylic denture base on C. albicans adhesion has not been investigated. The aim of this study was determine whether adding neem powder to acrylic denture base materials could reduce Candida albicans adhesion. Conclusions: The results suggest that adding neem powder to acrylic resin denture base materials reduces the adhesion of C. albicans; the incorporation of neem could be a possible denture stomatitis prevention method
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