Abstract
A licensed inactivated seasonal influenza vaccine produced in canine kidney cells (MDCK 33016-PF) contains no egg proteins and did not trigger degranulation in rat basophilic leukemia (RBL) cells passively sensitized with human anti-dog IgE, supporting its safe use in dog-allergic individuals. The canine kidney cell-derived H1N1 pandemic vaccine, however, was adjuvanted with the emulsion adjuvant MF59®, and support for its similar safe use was sought. We evaluated allergenicity of the adjuvanted canine kidney cell-derived H1N1 vaccine in subjects with dog allergy, with utilization of an in vitro mediator release assay.
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