Abstract
A new method is described for the assessment of the dissolution behavior of solid dosage forms. The method, which is based on the mass transfer between solid and liquid phase in an exchange column, is shown to avoid some disadvantages of the commonly used beaker methods employing fixed liquid volumes. Its usefulness is demonstrated by results obtained with nondisintegrating and uniform granules of benzoic acid in water. The influence of various external parameters, such as liquid flow rate, cell cross-sectional area, amount of material, and particle diameter, is found to agree with theory and literature data. Because of its reproducibility and the absence of arbitrary external parameters, the method seems to be useful for a meaningful study of dissolution kinetics.
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