Abstract
In vitro Assessment of Antimicrobial Activity of Zinc Oxide Nanoparticles against Pathogenic Streptococcus parauberis
Highlights
Streptococcal infection is a major bacterial problem that affects a wide variety of fish species, causing heavy economic losses in the aquatic industry in multiple countries all over the world (Baeck et al, 2006; Cai et al, 2016)
Transmission Electron microscopy results zinc oxide (ZnO) nanoparticles (ZnO NPs) treated bacterial culture revealed attachment of the NPs to the bacterial cell membranes, and NPs were noticed in the cell cytoplasm with concomitant rupture of the cell membrane and release of intracellular contents
The optical density of S. parauberis culture control group was three-fold higher than ZnO NPs treated group which indicate that ZnO NPs were capable to significantly decrease bacterial cell viability
Summary
Streptococcal infection is a major bacterial problem that affects a wide variety of fish species, causing heavy economic losses in the aquatic industry in multiple countries all over the world (Baeck et al, 2006; Cai et al, 2016). Streptococcosis is caused by various streptococcal species (Lazado et al, 2017), chief among them, Streptococcus parauberis (S. parauberis). It is a non-motile, α- hemolytic, gram-positive cocci belongs to family Streptococcacea (Nho et al, 2011). Serious public health problems and zoonotic potential from some streptococcal species including S. parauberis have been reported (Ghittino et al, 2003; Zaman et al, 2016). Molecular-based approaches for vaccinations have been described for S. parauberis, the majority of commercial vaccines have been confronted with limit-
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