Abstract
Purpose: To synthesize graphene-based silver nanocomposites and evaluate their antimicrobial and anti-Tomato Bushy Stunt Virus (TBSV) activities.Methods: A graphene-based silver composite was prepared by adsorbing silver nanoparticles AgNPs to the surfaces of graphene oxide (GO) sheets. Scanning electron microscopy was used to analyze the morphology of the synthesized graphene-based silver nanocomposite. This compound was investigated for its antimicrobial activity against several multidrug-resistant human pathogens using the agar well diffusion technique. Moreover, the biocompatibility and antiviral activity of the graphene-based nanocomposite against TBSV was studied in lettuce.Results: The graphene-based silver composite exhibited remarkable antimicrobial effects against pathogenic bacteria including Shigella sonnei and Pseudomonas aeruginosa with zones of inhibition of 32 ± 0.11 and 29 ± 0.05 mm, respectively. They inhibited TBSV better than graphene and GO.Conclusion: The synthesized graphene-based silver composite exhibits potent activity against TBSV and multidrug resistant bacteria, indicating that they are good candidates for future therapeutic applications.Keywords: Graphene oxide, Graphene-based nanocomposite, Antiviral, Antimicrobial, Multidrugresistant (MDR) human pathogens
Highlights
The most versatile application for graphene is its use in composite materials
graphene oxide (GO) is applied in medicine, agriculture, food, aerospace, electronics and defense industries [4]
After incubation at 37 °C for 24 h with Gr or GO, no inhibition zone was observed for the fungus C. albicans
Summary
Low production costs make graphene-based composites attractive and competitive for a variety of uses [1,2,3]. The antimicrobial characteristics of graphene-based composite materials have promoted their use in medical and ecological applications and various consumer goods [10]. The present work investigated the development and analysis of graphene-based antimicrobial and antiviral agents. GO (1.0 g) was dispersed in 75 ml double distilled water To this solution, the required amount of silver nitrate and tri-sodium citrate were added {(AgNO3) : (trisodium citrate) = 2}. After 25 days of planting, Lettuce seedlings were inoculated with TBSV. Lettuce plants were inoculated in a randomized block design with three seedlings per pot, one pot per replicate, and four replicates per treatment (total 12 seedlings per treatment).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
