Abstract
A viral fraction has been isolated from poliovirus-infected HeLa cells which sediments at 10 S and which contains virus-specific polypeptides closely resembling those of 73 S empty capsids. In the presence of infected cell extracts, the 10 S material is assembled to a 73 S product indistinguishable from natural empty capsids by sedimentation behavior or by polypeptide analysis with gel electrophoresis. Kinetic experiments suggest that the 10 S and 73 S components are sequential precursors of the complete virion.
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