Abstract
In vitro Assay of Alpha-Glucosidase Inhibitor Activities of Three Seagrasses from Banten Bay, Indonesia
Highlights
Diabetes mellitus (DM) is an endocrine disorder characterized by high blood glucose levels
Seagrass is known as a plant containing bioactive compounds, especially for therapy antidiabetic.This research aims to evaluate the α-glucosidase inhibition activity of three species seagrasses (Enhalus acoroides, Thalassia hemprichii and Cymodocea rotundata) from the Banten Bay, Indonesia
The result showed that the 80% ethanol extracts of Enhalus μg/mL) had the most potential α-glucosidase inhibitors aacctoivroitiydecsom(ICp5a0rveadluwesith16t8h.e15p±os2it.i7ve[1] control acarbose, Thalassia hemprichii and Cymodocea rotundata (IC50 values 197.27 ± 3.07 μg/mL, 425.86 ± 5.15 μg/mL and 429.28 ± 8.89 μg/mL)
Summary
Diabetes mellitus (DM) is an endocrine disorder characterized by high blood glucose levels. Handling of diabetes mellitus can be done through inhibition of the α-glucosidase enzyme that catalyzes the final step of starch digestion and abundant disaccharides in the human diet on the border of the small intestine mucosal brush.[1,2] Seagrasses are marine angiosperms growing abundantly in the sea that produce secondary metabolites as an antidiabetic,[3] antioxidant[3,4] and antibacterial[5,6] activities with the chemical compound such as phenol, flavonoids, tannin, terpene, sterol.[6,7] The aim of the present work is to investigate the α-glucosidase inhibitory activities of three seagrasses in Banten Bay, Indonesia i.e. Enhalus acoroides, Thalassia hemprichii and Cymodocea rotundata extracts
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