Abstract
The objective of this study was to investigate extracts from the peels of <i>Annona squamosa</i> L. (purple sugar apple), <i>Annona reticulata</i> L. (custard apple), <i>Chrysophyllum cainito</i> L. (green star apple), and <i>Melicoccus bijugatus</i> Jacq. (mamoncillo), as potential sources of anti-HIV-1 agents. Methanolic extracts from the peels of the aforementioned tropical fruits were obtained by maceration. Antiviral activity was evaluated through HIV-1 RT inhibition by extracts, using a non-radioactive immuno/colorimetric assay (Lenti RT Activity Assay, Cavidi Tech). Assay was performed according to the protocol provided by the manufacturer. Extracts from the peels of <i>A. squamosa, A. reticulata</i>, and <i>C. cainito</i> showed high antiviral activity, with HIV-1 reverse transcriptase inhibition values of 96.45 ± 2.08%, 78.63 ± 0.97%, and 72.55 ± 2.26%, respectively. These results demonstrate that <i>A. squamosa, A. reticulata</i>, and <i>C. cainito</i> have significant antiviral activity in their peels and can therefore be regarded as potential sources of anti-HIV-1 agents.
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