Abstract
The antioxidant and anti-proliferative effects of dichloromethane fraction from methanol extract of Liriodendron tulipifera were investigated in this study. Scavenging effects on the α,α-diphenyl-picrylhydrazyl (DPPH) and nitrite radicals, and protection against reactive oxygen species induced lipid, protein and deoxyribonucleic acid (DNA) damage were evaluated. The dichloromethane fraction of L. tulipifera exhibited high antioxidant activities to scavenge DPPH and nitrite radicals, ferric reducing power and protection against biological macromolecular oxidative damage. Furthermore, the dichloromethane fraction of L. tulipifera exhibits the anti-proliferative activity and induction of the G2/M arrest in human colon tumor HT-29 cells. These results demonstrate potential antioxidant activities and anti-proliferative effect of L. tulipifera, as an antioxidant for diseases caused by reactive oxygen species. Key words: Free radical, lipid peroxidation, protein oxidation, DNA damage, G2/M arrest.
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