Abstract
ObjectiveThe study was aimed at evaluating the in vitro antioxidant potential of methanolic and aqueous extract of Ardisia solanacea leaves. MethodsThe leaves were screened for possible antioxidant property by 2,2 diphenyl-1-picryl hydrazyl radical scavenging (DPPH), superoxide radical and hydroxyl radical scavengings, reducing power, metal ion-chelating and lipid peroxidation assays. The total phenolic and flavonoid contents were also determined. ResultsThe plant leaves contained moderate quantity of phenols and flavonoids. The methanolic extract of the plant leaves showed powerful DPPH (IC50 value of 198.43 ± 1.30 μg/ml) and hydroxyl radical scavenging activity (89.34%). However the extract showed only moderate lipid peroxidation and superoxide radical scavenging activity. In metal ion-chelating assay, the aqueous extract showed better radical scavenging activity (IC50 value of 683.04 ± 2.20 μg/ml) than methanolic extract (IC50 value of 1843.41 ± 4.3 μg/ml). ConclusionThe results obtained in the present study indicate that the leaves of A. solanacea exhibit potent DPPH, metal ion, hydroxyl radical, reducing power activity and the methanolic extract is better radical terminator than the aqueous.
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