Abstract
The alarming rate of diabetes mellitus (DM) globally is bothersome and has drawn the search light of researchers on naturally endowed phytonutrients being an alternative in managing the menace. Therefore, the current study was designed to investigate some antioxidant parameters embedded in the extract of Dialium indium (DI) fruit pulp and also, to elucidate its antidiabetic potentials through the inhibition of two key carbohydrate-metabolizing enzymes such as α-amylase and intestinal α-glucosidase. Hydro-ethanolic extract of DI fruit pulp was used for the antioxidants and enzyme inhibitory bioassays through various convectional antioxidant assay methods in vitro. In the results, total phenolic content of the extract had; 6.74 ±3.38 mg GAE.g-1, total flavonoid contents; 0.02 ±0.01 mg QE.g-1 and FRAP; 0.84 ±0.47 mg AAE.g-1 dried sample. Also, there was a marked significant (p <0.05) difference observed in the inhibition of α-amylase and intestinal α-glucosidase by the different concentrations of the extract used in concentration-dependent manner with their different EC50. The inhibition demonstrated against these two carbohydrate metabolizing enzymes possibly could be through the embedded antioxidant potentials of the fruit pulp and this if properly harnessed, it could be helpful in the management of type 2 diabetes.
Highlights
Type 2 diabetes (T2D) is a common and chronic disorder caused by impaired cellular carbohydrate metabolism characterized by elevated serum glucose level (Beverley and Eschwège, 2003)
The inhibition demonstrated against these two carbohydrate metabolizing enzymes possibly could be through the embedded antioxidant potentials of the fruit pulp and this if properly harnessed, it could be helpful in the management of type 2 diabetes
The results indicated significant (p
Summary
Type 2 diabetes (T2D) is a common and chronic disorder caused by impaired cellular carbohydrate metabolism characterized by elevated serum glucose level (Beverley and Eschwège, 2003). Regulation of postprandial hyperglycemia level is important in delaying or preventing T2D (Madhusudhan and Kirankumar, 2015), therapeutic approach is a common strategy for decreasing postprandial hyperglycemia in T2D patients, through which there is inhibition of sugar metabolizing enzymes such as alphaglucosidase and alpha-1,4-glucan-4-glucanohydrolases in the gastrointestinal tract (GIT) (Krentz and Bailey, 2005; Shim et al, 2003). These inhibitions cause reduction in the carbohydrate digestion process and subsequently lessening the postprandial plasma glucose rise (RhabasaLhoret and Chiasson, 2004).
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