Abstract
Astaxanthin is a potent antioxidant compared with vitamins and other antioxidants. However, astaxanthin extract from shrimp processing waste has not yet been used in cosmetic products. This study aimed to explore the natural astaxanthin from shrimp shells for antioxidant and antityrosinase activities as well as potential toxicity. The antioxidant activities were performed with 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging, β-carotene bleaching, and singlet oxygen quenching assays. The results revealed that astaxanthin extract demonstrated potent antioxidant activities against DPPH and ABTS radicals, and prevented the bleaching of β-carotene and quenching of singlet oxygen (EC50 17.5 ± 3.6, 7.7 ± 0.6, 15.1 ± 1.9 and 9.2 ± 0.5 μg/mL, respectively). Furthermore, the astaxanthin extract could inhibit tyrosinase activity (IC50 12.2 ± 1.5 μg/mL) and had no toxic effects on human dermal fibroblast cells. These results suggested that shrimp astaxanthin would be a promising dietary supplement for skin health applications.
Highlights
Astaxanthin is a ketocarotenoid synthesized by plants and microorganisms but is distributed mainly in aquatic animals such as crustaceans, salmon, and trout
The ethanol extracted astaxanthin yield in the form of red-orange paste was 28.9 ± 3.2 mg/g shrimp shells. This result is similar to a previous study by Taksima et al [4] who reported that extraction of astaxanthin from shrimp shells with ethanol obtained a yield of 24.7 ± 2.9 mg/g shrimp shells
Characteristics confirm astaxanthin induced cytotoxicity, we investigated the changes of cell morphology in WS1 human dermal fibroblast cellscytotoxicity, exposed to 5–160 μg/mL astaxanthin forof
Summary
Astaxanthin is a ketocarotenoid synthesized by plants and microorganisms but is distributed mainly in aquatic animals such as crustaceans, salmon, and trout. Shrimp waste is one of the important natural sources of carotenoid; astaxanthin and its esters as the major pigments. Several methods for extraction of astaxanthin have been attempted. Ethanolic extract of astaxanthin was used to fortify in yogurt as an optional functional food for consumers [4] and was investigated the anti-inflammatory effect on alveolar macrophages [5]. The extract from shrimp waste has not been yet studied on skin effect
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