Abstract
Introduction: All parts of the mango plant contain secondary metabolites that possess several beneficial properties. In the present study, evaluation of in vitro anti-oxidant, anti-microbial and anti-inflammatory activities of five Indian cultivars of mango fruit peel extracts were carried out.Methods: Different solvent (hexane, ethyl acetate, and methanol) extracts of five Indian cultivars of mango fruit peels were prepared by using soxhalate, and the aqueous extract was prepared by maceration. In vitro anti-oxidant activities of these extracts were determined by using 2,2-Diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azinobis 3-ethylbenzothiazoline-6-sulfonic acid (ABTS), hydrogen peroxide (H2O2) and nitric oxide (NO) radical scavenging methods. Their anti-microbial and anti-inflammatory activities were determined by agar-well diffusion and HRBC (human red blood cell) methods, respectively.Results: All the five mango peel extracts showed good anti-oxidant activities, especially the methanolic extract of peel of Sindhura cultivar showed better IC50 values of DPPH (21.62±1.82 μg/mL), ABTS (21.33±1.94 μg/mL), H2O2 (19.87±2.61 μg/mL) and NO (57.29±2.17 μg/mL) radical scavenging activities than other extracts. It also possessed higher contents of phenolics (169.18±3.28 mg of GAE/g) and flavonoids (26.18±1.84 mg of QE/g) than the other extracts. All peel extracts of five cultivars of mango fruit revealed good anti-microbial activities against bacterial and fungal cultures and also possessed significant anti-inflammatory activity.Conclusion: The present study revealed that all the mango peel extracts have potential antioxidant activity, as well as better anti-microbial and anti-inflammatory activities.
Highlights
All parts of the mango plant contain secondary metabolites that possess several beneficial properties
Many scientists have reported that microorganisms are the causal agents of food-borne diseases and food spoilage [8,9], which raises the necessity for anti-microbial agents [10]
The results revealed that the phenolics content of methanolic peel extract of Sindhura cultivar had the highest total Total phenolics content (TPC) as compared to the extracts of other cultivars peels
Summary
All parts of the mango plant contain secondary metabolites that possess several beneficial properties. In vitro anti-oxidant activities of these extracts were determined by using 2,2-Diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azinobis 3-ethylbenzothiazoline-6-sulfonic acid (ABTS), hydrogen peroxide (H2O2) and nitric oxide (NO) radical scavenging methods Their anti-microbial and anti-inflammatory activities were determined by agar-well diffusion and HRBC (human red blood cell) methods, respectively. Results: All the five mango peel extracts showed good anti-oxidant activities, especially the methanolic extract of peel of Sindhura cultivar showed better IC50 values of DPPH (21.62±1.82 μg/mL), ABTS (21.33±1.94 μg/mL), H2O2 (19.87±2.61 μg/mL) and NO (57.29±2.17 μg/mL) radical scavenging activities than other extracts It possessed higher contents of phenolics (169.18±3.28 mg of GAE/g) and flavonoids (26.18±1.84 mg of QE/g) than the other extracts.
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