Abstract
In the present study locally available plant Nymphoides hydrophylla was screened for its in - vitro antioxidant and in - vivo hepatoprotective activity. The In vitro antioxidant activity of Nymphoides hydrophylla was studied using four types of oxyge n free radical systems . Nymphoides hydrophylla had effective scavenging abilities against free radicals which was determined using standard methods like DPPH, Reducing power method, Nitric oxide assay and Phosphomolybdenum methods against standard gallic a cid. The In - vivo hepatoprotective effect of Nymphoides hydrophylla was evaluated in Carbon tetrachloride (CCl 4 ) induced albino rats for acu te liver injury . The animals were divided into six groups, each group containing three animals and two different dose s of the extract were administered orally for five days. The hepatoprotective activity was assessed by estimating various biochemical parameter s and histopathological studies . CCl 4 administration caused severe hepatic damage in rats as e videnced by elevate d SGPT, SGOT , alkaline phosphatase (ALP) and total bilirubin levels. The ethanolic whole plant extract of Nymphoides hydrophylla significantly lowered the biologi cal indicators and the results we re compared with th at of standard drug Silymarin. The histopa thological study of liver was carried out and observed. The present study concludes that e thanolic whole plant extract of Nymphoides hydrophylla has significant antioxidant activity and succeeded to restore the biochemical parameters and improved the histo logical alteration of the liver.
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