In vitro antioxidant activity and in vivo aphrodisiac activity in male Cavia porcellus of Albizia adianthifolia (Schum.) W. Wight and Pericopsis angolensis (Baker) Meeuwen

Alombong Alonie Gracia Alombong Alonie Gracia,Manya Mboni Henry Manya Mboni Henry,Bakari Amuri Salvius Bakari Amuri Salvius,Kamwimba Mahungala Arlette Kamwimba Mahungala Arlette,Bashige Chiribagula Valentin Bashige Chiribagula Valentin,Okusa Ndjolo Philippe Okusa Ndjolo Philippe

doi:10.30574/wjbphs.2021.5.3.0024

Alombong Alonie Gracia Alombong Alonie Gracia, Manya Mboni Henry Manya Mboni Henry + Show 4 more

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https://doi.org/10.30574/wjbphs.2021.5.3.0024

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Abstract

This study was carried out to evaluate the aphrodisiac and antioxidant activities of aqueous and methanolic extracts of two plants used as aphrodisiac in traditional medicine in Kampemba municipality, in Lubumbashi DR Congo. Aqueous and methanolic root bark extracts of both Albizia adianthifolia and Pericopsis angolensis were administered orally to male Cavia porcellus before evaluating their physical behavior in the presence of females and their testosterone, cholesterol and triglyceride contents. The antioxidant activity was determined by the DPPH method. At 200 and 250 mg kg-1 body weight (bw), the extracts exhibited a decrease in rise time and intromission time and an increase in ejaculation time, ascending frequency, intromission frequency, ejaculation frequency and testosterone compared to the control group that received sildenafil (10 mg kg-1 bw) used as a reference. A positive relationship between testosterone level and antioxidant activity has also been observed. The aphrodisiac and antioxidant activity observed in the two species justify their uses in traditional medicine as aphrodisiacs. Further work is needed in order to proceed to the isolation and the identification of the active compounds.

Highlights

Erectile dysfunction (ED) refers to the constant inability of a man to achieve or maintain an erection for satisfactory sexual activity [1]
Declines are recorded for rise time (RT), intromission time (IT) and postejaculatory interval (PEI) unlike ejaculation time (ET), number of displays (ND), number of intromissions (NI) and number of ejaculations (NE) which increased
The EM of A. adianthifolia seem more efficient than the EA unlike P. angolensis where the performances between the two extracts (EA and EM) seem to be of the same amplitude

Summary

Introduction

Erectile dysfunction (ED) refers to the constant inability of a man to achieve or maintain an erection for satisfactory sexual activity [1]. Plants called aphrodisiacs, in memory of Aphrodite, the Greek god of love, such as Pausinystalia johimbe Several plants are still used today as aphrodisiacs in several cultures. Wight (Fabaceae), [Synonyms: Albizia fastigiata (E.Mey.) Oliv. Non (JFGmel.) CASm.] and, Pericopsis angolensis (Baker) Meeuwen (Fabaceae), [synonym: Afrormosia angolensis (Baker) Harms.], are two plants widely used in traditional medicine in the treatment of sexual dysfunction in the Kampemba municipality in DR Congo. Albizia adianthifolia is used as a purgative and antidiabetic as well as in eye, gastrointestinal, hemorrhoidal, cephalic, Corresponding author: Bashige Chiribagula Valentin Department of Therapeutic Chemistry-Faculty of Pharmaceutical Sciences - University of Lubumbashi - 27, av Kato, Municipality of Kampemba, Lubumbashi -DR Congo

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