Abstract
In the present study, we report antibacterial and antioxidant activities of bioactive compounds extracts (ethyl acetate extract, methanolic extract, n-hexane extract) of Streptomyces lydicus A2 isolated from air in Sciencetific and Technological Equipments Building, Walailak University, Thailand. The S. lydicus A2 is potential to produce bioactive compounds showed various biological activities. In previous research, its culture broth or extract shows antimicrobial activitie. In this study, extract prepared from S. lydicus A2 stored at -80 oC was re-evaluated the antimicrobial activity when grew in various medium and incubation time to find out storage effect toward the antimicrobial activity. The extract (fractions) from S. lydicus A2 still inhibit test bacteria eventhough it decreases 50% than the extract prepared from S. lydicus A2 without -80 oC storage. Antimicrobial activity against Staphylococcus aureus and Bacillus cereus was only exhibited by the methanolic fraction S. lydicus A2. Only, the ethyl acetate extract was found to possess dose dependent DPPH free radical scavenging. The isolate A2 could be a potential candidate for the development of novel therapeutic agents active against pathogens and free radicals. Further studies on genomic characterization of isolate and structure determination of the bioactive compounds are under progress.
Highlights
Actinomycetaceae are the group of microorganisms as the source of secondary metabolites, pivotal compounds, for drug-based recovery due to biological activities of those compounds
We report antibacterial and antioxidant activities of bioactive compounds extracts of Streptomyces lydicus A2 isolated from air in Sciencetific and Technological Equipments Building, Walailak University, Thailand
The study was successful in the isolation and investigation of antagonistic actinomycetes from air sample collected at Walailak University, Thailand
Summary
Actinomycetaceae are the group of microorganisms as the source of secondary metabolites, pivotal compounds, for drug-based recovery due to biological activities of those compounds. From all the genera of actinomycetes, the genus Streptomyces is represented in nature by the largest number of species and varieties. These species can produce a large number of antibiotic and active secondary metabolites (Devi et al, 2006). The genus Streptomyces which shows the highest contribution in production bioactive compounds especially antimicrobial activity. Apart from antimicrobial activity, Streptomyces exhibit other activities. KR-5 exhibited cytotoxic activity against the growth of human breast cancer cell line (Sateesh et al, 2011). SRDP-H03(Rakesh et al, 2013) and BI244
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