In vitro antimicrobial activity of CP-99433 compared with other fluoroquinolones

Abstract

CP-99433 is a new C-7 diazabicyclofluoroquinolone with a broad spectrum of activity that includes Enterobacteriaceae, Gram-positive cocci, and nonenteric Gram-negative bacilli. Potent activity was demonstrated against Pseudomonas aeruginosa [minimum inhibitory concentration (MIC 90, 0.5 μg/ml), Xanthomonas maltophilia (MIC 90, 1 μg/ml), and all Streptococcus species (MIC 90s, 0.25–1 μg/ml). Only CP-99433 was active against Enterococcus faecium (MIC 50, 2 μg/ml). CP-99433 also demonstrated activity against several ciprofloxacin-resistant staphylococci. Additional studies of CP-99433 activity appear indicated.