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Abstract
Objective: This study aimed to determine the potential inhibitory effects of Eleutherine bulbosa on the growth of Plasmodium falciparum and its toxiceffects on lymphocyte cells.Methods: We performed a 50% inhibition concentration (IC50) test of E. bulbosa against P. falciparum, used transmission electron microscopy (TEM)to observe Plasmodium morphology after exposure to E. bulbosa, and determined E. bulbosa’s cytotoxic concentration 50% (CC50) against lymphocytes.Results: The IC50 value of E. bulbosa was 0.62 μg/ml. We observed crystals in the mitochondria of parasites under TEM. CC50 values at 24 h and 72 hwere 851.14 μg/ml and 707.94 μg/ml, respectively.Conclusion: The main content of E. bulbosa is naphthoquinones that are suspected of having a mitochondrial target on the malaria parasite. E. bulbosais not toxic to lymphocytes; therefore, it has a potential as an antimalarial therapeutic.
Highlights
Malaria is a life-threatening disease that has killed many children aged
Observation of P. falciparum morphology under transmission electron microscopy (TEM) The morphological differences of untreated and treated P. falciparum parasites are observed in Figs. 2 and 3
Analysis of the toxicity effect of E. bulbosa on lymphocyte cells In the toxicity test of E. bulbosa, lymphocyte cells were used because blood is exposed to chemical compounds/drugs consumed
Summary
Malaria is a life-threatening disease that has killed many children aged
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