Abstract
This study analyzes the antileishmanial activity of the crude ethanol extract, fractions, and isolated compounds of A. othonianum nuts. Antileishmanial activity was evaluated against Leishmania amazonensis promastigotes in vitro. The phytochemical study was performed by high-performance liquid chromatography-high-resolution mass spectrometry-diode array detector (HPLC-HRMS-DAD) and by preparative HPLC. HPLC-HRMS-DAD analysis of the bioactive extract confirmed the presence of ten alkyl phenol derivatives that had previously been isolated from A. occidentale. Bioassay-guided isolation afforded cardanol triene, cardanol diene, cardanol monoene, cardol triene, anacardic acid triene, anacardic acid diene, and anacardic acid monoene. Cardol triene gave an IC50 of 80.66 µM. The obtained data suggest that the evaluated extract, fractions, and cardol triene had moderate activity against L. amazonensis promastigotes. This is the first description of alkyl phenols in A. othonianum.
Highlights
This study analyzes the antileishmanial activity of the crude ethanol extract, fractions, and isolated compounds of A. othonianum nuts
The crude extract obtained from A. othonianum nuts has not yet been investigated
The HPLC-HRMS-DAD data of the crude ethanol extract of cashew nuts were obtained on an LC-20AD HPLC (Shimadzu, Kyoto, Japan) and micrOTOF-QII ESI mass spectrometer (Bruker Daltonics, Billerica, MA, USA)
Summary
This study analyzes the antileishmanial activity of the crude ethanol extract, fractions, and isolated compounds of A. othonianum nuts. Atividade antileishmania in vitro de Anacardium othonianum e substâncias isoladas em Leishmania amazonensis The crude ethanol extract of A. othonianum leaves presents antifungal activity.
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