Abstract

Oligomeric and polymeric proanthocyanidins extracts from Erythroxylon laurifolium (Erythroxylaceae) and Krameria triandra (Krameriaceae), were found to have moderate activity against Herpes simplex virus type 1. No notable differences were found between the two types of compounds or plants. Proanthocyanidins did not affect viral attachment or penetration but did affect further events in the replicative cycle. An enzymatic inhibition was suggested. Direct inactivation of virus was found at high concentrations and may partially contribute to the antiviral effect of tannins.

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