Abstract
Background: Antifungal multidrug resistance has been reported worldwide and has stimulated investigations of plant
 species for the treatment of candidiasis. In particular, in vitro antifungal activities and cytotoxicity of dry extracts from
 Ceasalpinia ferrea (tul.) Martius, Brosimum acutifolium Huber, and Salacia impressifolia (Miers) A.C. Smith were
 evaluated.
 Materials and Methods: Minimum inhibitory concentrations (MIC) and minimum fungicide (MFC) values were
 established according to the protocol M27-A2 of the Clinical and Laboratory Standards Institute (CLSI). Subsequent
 evaluations were performed using strains of Candida albicans from the American Type Culture Collection (ATCC)
 10231, clinical isolated Candida albicans, Candida glabrata (CCT) 0728, Candida krusei (FTI) CCT 1517, and
 Candida guilliermondii (CCT) 1890. Morphological changes were evaluated using scanning electron microscopy
 (SEM), and cytotoxicity was evaluated in murine L929 fibroblast cells after treatment with plant extracts.
 Results: MIC values indicated antifungal potential of all three extracts against the main fungi that causes candidiasis.
 Conclusion: In particular, C. ferrea showed promising antimicrobial potential against all strains. Hence, future studies
 are warranted to investigate pharmacologically active compounds from this extract that could be used as prototypes for
 drug development and/or as a source of raw pharmaceutical materials for the treatment of candidiasis.
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