In vitro antidiabetic and thrombolytic activity of ethanolic extract of Phyllanthus acidus (L) Skeels (EEPA)

Abstract

Phyllanthus acidus (L). Skeels is a tropical tree belonging to the Phyllanthaceae family. It is commonly known as star gooseberry and it is a highly nutritious edible fruit but also used to treat a wide spectrum of diseases such as inflammatory, rheumatism, bronchitis, asthma, respiratory disorder, hepatic diseases and diabetes in India, Asia, the Caribbean region, and Central and South America. This study aims to determine the invitro anti diabetic and invitro thrombolytic effect of ethanolic extract of Phyllanthus acidus. Invitro antidiabetic activities were performed by comparing it with standard (Acarbose). The extract showed comparable α-amylase (IC50 44.38 µg/ml) and α-glucosidase inhibition activity (IC50 38.29 µg/ml). The highest concentration of ethanolic extract of Phyllanthus acidus exhibited the utmost clot lysis (60.71 %) property compared to standard streptokinase (SK) (64.1%). The present study highlighted that the ethanol extract of Phyllanthus acidus has antidiabetic and thrombolytic activities that can be further explored for novel drug development.