In vitro anticandidal activity of the secondary metabolites extracted from Saussurea Costus (Falc.) lipschitz roots

Abstract

The present study, was conducted to investigate the effect of the crude Alkaloids, Flavonoids, and Terpenoids compounds extract from roots of (Saussurea costus) against Candida species isolated from different clinical samples such as mouth and vagina in the province of Babil 2021 in Iraq. Anticandidal activity was achieved in vitro by using agar well diffusion method against Candida species by preparing three concentrations for each crude compound (25, 50, and 100) mg/ml and compared to positive control represented by Fluconazole 50mg/ml and negative control represented by 10% dimethyl sulfoxide. The aim of this study was to control of Candida species isolated different clinical samples such as mouth and vagina by using secondary metabolites extracted from seeds of Carthamus tinctorius L. The data collected from the study revealed that, the crude Alkaloids, Flavonoids, and Terpenoids compounds extract from seeds of (Saussurea costus) showed reduction at P≤ 0.05 in the growth of Candida species especially at 100mg/ml compared with negative control. Finally, it can be concluded that Saussurea costus is most effective in controlling Candida species, especially Terpenoid and Alkaloids compounds.