Abstract
Semecarpus anacardium (SA) is a plant native to India that is eaten as a fresh vegetable on a daily basis. The effects of SA therapy on human breast cancer MCF-7 cell lines were investigated in this study. Maceration with various solvents was used to prepare the crude extract of flavonoid fraction from SA bark, and fractionation was done using TLC and column chromatography techniques. MTT assay was used to assess the effects of the isolated flavonoid fraction of SA bark on cell viability. SA decreased MCF-7 cancer cell viability in a concentration-dependent manner, with IC50 values of 24.18+1.20 μg/mL and 12.08+1.18 μg/mL after 24 and 48 hours of treatment, respectively. Finally, SA flavonoid fraction effectively reduced MCF-7 cells, implying that SA flavonoid fraction has anticancer potential against MCF-7 cells and may be useful in the prevention and treatment of breast cancer.
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