Abstract
Saurauia vulcani plants grow naturally in North Sumatra, Indonesia. This plant is commonly used as an antidiabetic drug and a cure for other digestive ailments. The objective of this study was to examine the phytochemical characteristics and anti-colorectal-cancer activity of the extract from leaves of Saurauia vulcani plants. The method employed was to test phytochemicals that included the presence/detection of alkaloids, saponins, flavonoids, triterpenoids/ steroids, tannins, and hydroquinone in the leaf extract. The anti-colorectal-cancer activity was tested in vitro using the MTT method, against WiDr and HCT 116 cancer cells, with the liquid fractions of n-hexane, ethyl acetate, and methanol solvents. Phytochemical analysis results showed that Saurauia vulcani leaf extract contained tannins, saponins, flavonoids, and terpenoids. Chemical component analysis of ethyl acetate fraction showed the presence of fatty acid groups. The n-hexane, ethyl acetate, and methanol fractions exhibited cytotoxicity against the WiDr cell line, with IC50 values of 456.19, 97.41 and 191.92 ppm, respectively. Meanwhile, the cytotoxicity activity of the leaf extract against the HCT cell lines was accomplished at IC50 values of 777.35, 568.53 and 529.39 ppm, correspondingly with n-hexane, ethyl acetate and methanol fractions, respectively. The leaf extract in ethyl acetate fraction was indicatively the best in efficaciously inhibiting the WiDr cells
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