Abstract
Novel binuclear metal complexes of general formula [M2(PymL)X3] (where: M=Cu(II), Ni(II), Co(II) or Zn(II); X=Cl− or CH3CO2− and PymL=C13H17N4O6) were synthesized by template condensation of Schiff base (L) derived from glycine using 2,3-butanedione, 5-methyl-2,6-pyrimidine-dione and metal chloride/acetate salt in 1:1:2 stoichiometric ratio. Synthesized compounds were characterized by elemental analysis, conductance measurement, magnetic measurement, IR, UV–visible, 1H NMR, 13C NMR, EPR and ESI-MS spectral studies. IR spectral data suggest that Schiff base (L) behaves as tetradentate ligand with two nitrogen and two oxygen donor sites of the azomethine group and carboxylic group, respectively and 5-methyl-2,6-pyrimidine-dione behaves as tridentate ligand with two oxygen atoms of the carbonyl group and one nitrogen atom of pyrimidine ring as binding sites. Physico-chemical data suggest octahedral geometry and non-electrolytic nature of metal complexes. The compounds were evaluated for their antimicrobial property by in vitro antimicrobial screening against bacteria Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Salmonella typhi and fungi Candida albicans and Candida parapsilosis. The results indicate that metal complexes exhibit more activity than free Schiff base (L) against studied bacteria and fungi.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
