Abstract
There is a continuous need for discovering new nanomaterials with antibacterial activity against various pathogens, like Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). This study was performed to assess the antimicrobial activity of two novel nanostructured forsterites, both in the absence and the presence of silver nanoparticles (AgNPs). The two nano forsterites (FS) were prepared by advanced sol-gel (FSsg) and precipitation (FSpp) methods. Preparation of colloidal AgNPs systems was realized by using the precursor, AgNO3, and the trisodium citrate and tanic acid assuring the formation and stabilization of AgNPs. The characterization of nano forsterite powders was carried out using complementary physical methods: XRD, SEM, and AFM. The AgNPs were characterized by UV-Vis spectra, STEM and AFM imaging. The antimicrobial activity was studied by the agar well diffusion method both in the FS native state, as FSsg and FSpp, and in their mixture with silver nanoparticles (AgNPs). The inhibitory effect of synthesized forsterites, FSsg and FSpp, particularly variants with AgNPs was found only on the S. aureus strain, the zones of inhibition being between 8 and 10 mm, and more intensely expressed in the FSpp-AgNPs dispersions. These findings open new orthopedic applications of these systems, particularly for antimicrobial coated metallic implants.
Highlights
There is a continuous need for discovering new nanomaterials with antibacterial activity against various pathogens, like Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli)
While most of them involve the addition of silver nanoparticles, AgNPs, known for their antibacterial effect, there are some materials credited to possess intrinsic antibacterial properties
STEM images of the AgNPs colloidal solution were obtained with a combined scanning electron (SE) and scanning transmission electron (TE) microscope, Hitachi HD-2700, operated at a maximum accelerating voltage of 200 kV
Summary
There is a continuous need for discovering new nanomaterials with antibacterial activity against various pathogens, like Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). The inhibitory effect of synthesized forsterites, FSsg and FSpp, variants with AgNPs was found only on the S. aureus strain, the zones of inhibition being between 8 and 10 mm, and more intensely expressed in the FSpp-AgNPs dispersions These findings open new orthopedic applications of these systems, for antimicrobial coated metallic implants. It was reported that a 2 mg/mL sol-gel glycine-derived forsterite has an ability to inhibit S. aureus while an urea-derived one exhibit the same effect on both S. aureus and E. coli [8] The authors explain this activity of forsterite as a consequence of the increase in pH in the culture medium that is detrimental to bacterial development [8]. The antibacterial mechanism of forsterite containing systems is not yet understood
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