Abstract
Introduction: Using antibiotics to control pathogenic bacteria is associated with certain side effects in addition to emergence of drug resistance. Nowadays, researchers are considering using plants as suitable alternatives to antibiotics. The aim of study was to compare in vitro antimicrobial activities of aqueous and hydroalcoholic Bunium persicum and Rheum ribes L. extracts on Acinetobacter baumanii. Materials and methods: Different concentrations of R. ribes and B. persicum were prepared to determine microbial sensitivity of A. baumanii using disk diffusion, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC). Results: The highest MIC (256 µg/ml) against A. baumanii was derived for aqueous R. ribes and B. persicum extracts and the lowest MIC (128 µg/ml) for their hydroalcoholic extracts. The highest MBC (512 µg/ml) was derived for aqueous R. ribes extract and the lowest MBC (256 µg/ml) for aqueous and hydroalcoholic R. ribes and B. persicum and hydroalcoholic R. ribes extracts. The extracts exhibited great inhibitory effects against the studied bacteria in disk diffusion; and with increasing the extracts’ concentrations, the inhibitory effect was exhibited more markedly as increased diameter of inhibition zone. Conclusion: Hydroalcoholic R. ribes and B. persicum extracts can be used as nature-based compounds to control A. baumanii.
Highlights
Using antibiotics to control pathogenic bacteria is associated with certain side effects in addition to emergence of drug resistance
In this study, the antimicrobial activities of aqueous and hydroalcoholic R. ribes and B. persicum extracts were measured on A. baumanii; and the inhibitory effects of these extracts were measured with reference to presence or absence of inhibition zone, and the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were measured
The results on hydroalcoholic R. ribes and B. persicum extracts indicated that the MIC and MBC of both extracts were 128 and 256 μg/ml, respectively, for A. baumanii
Summary
Using antibiotics to control pathogenic bacteria is associated with certain side effects in addition to emergence of drug resistance. Acinetobacter baumanii is a gram-negative, nonmotile, and non-fermented coccus that is isolated mainly in hospital settings and ICUs. It is argued that this opportunistic pathogen is associated with nosocomial infections including urinary tract infections (UCIs), surgical site infections, meningitis, and occasionally infections of skin and central nervous system [1,2]. It is argued that this opportunistic pathogen is associated with nosocomial infections including urinary tract infections (UCIs), surgical site infections, meningitis, and occasionally infections of skin and central nervous system [1,2] This bacterium can grow in a wide range of pH and environmental temperature and uses different types of substances to grow [3]. Pharmaceutical and pharmacological industries have produced some new antibiotics during the last three decades, International Journal of Ayurvedic Medicine, 2019, 10(1), 47-51
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